王丽颖

博士后

个人简介

王丽颖，博士毕业于中国科学院动物研究所发育生物学，现为广州市妇女儿童医疗中心博士后。

研究领域

（1）配子发生尤其是减数分裂的翻译后修饰调控。
（2）卵母细胞发生及成熟机理研究

科研成果

主要科研成果（#共同第一作者, *通讯作者）如下：

1. Wang L#, Liu C#, Yang B#, Zhang H#, Jiao J#, Zhang R, Liu S, Xiao S, Chen Y, Liu B, Ma Y, Duan X, Guo Y, Guo M, Wu B, Wang X, Huang X, Yang H, Fang M, Zhang L*, Duo S*, Guo X*, Li W*. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. J Cell Biol. 2022 Jul 4;221(7):e202108015.


2. Wang L#, Liu C#, Wei H#, Ouyang Y, Dong M, Zhang R, Wang L, Chen Y, Ma Y, Guo M, Yu Y, Sun QY*, Li W*. Testis electroporation coupled with autophagy inhibitor to treat non-obstructive azoospermia. Mol Ther Nucleic Acids. 2022 Nov 9;30:451-464.


3. Wang L#, Xu Z#, Wang L#, Liu C#, Wei H, Zhang R, Chen Y, Wang L, Liu W, Xiao S, Li W*, Li W*. Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming. Cell Proliferation, 2021 Aug;54(8): e13080.


4. Wang L#, Zhang R#, Wu B, Li W*, Li S*, Liu C*. Autophagy mediated tubulobulbar complex components degradation is required for spermiation. Fundamental Research, 2022, 10(50)


5. Wang L#, Cao C#, Wang F, Zhao J*, Li W*. H2B ubiquitination: Conservedmolecular mechanism, diverse physiologic functions of the E3 ligase during meiosis. Nucleus, 2017, 8(5):461-468.


6. Liu C#, Wang L#, Li Y#, Guo M, Hu J, Wang T, Li M, Yang Z, Lin R, Xu W, Chen Y, Luo M, Gao F, Chen JY, Sun Q, Liu H, Sun B*, Li W*. RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. Nucleic Acids Res. 2023 Aug 11;51(14):7357-7375.


7. Liu C#, Xu W#, Wang L#, Yang Z#, Li K#, Hu J, Chen Y, Zhang R, Xiao S, Liu W, Wei H, Chen JY, Sun Q*, Li W*. Dual roles of R-loops in the formation and processing of programmed DNA double-strand breaks during meiosis. Cell Biosci. 2023 May 11;13(1):82.

代表性论著：

1. Wang L^#, Liu C^#, Yang B^#, Zhang H^#, Jiao J^#, Zhang R, Liu S, Xiao S, Chen Y, Liu B, Ma Y, Duan X, Guo Y, Guo M, Wu B, Wang X, Huang X, Yang H, Fang M, Zhang L*, Duo S*, Guo X*, Li W*. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. J Cell Biol. 2022 Jul 4;221(7):e202108015.

2. Wang L^#, Liu C^#, Wei H^#, Ouyang Y, Dong M, Zhang R, Wang L, Chen Y, Ma Y, Guo M, Yu Y, Sun QY*, Li W*. Testis electroporation coupled with autophagy inhibitor to treat non-obstructive azoospermia. Mol Ther Nucleic Acids. 2022 Nov 9;30:451-464.

3. Wang L^#, Xu Z^#, Wang L^#, Liu C^#, Wei H, Zhang R, Chen Y, Wang L, Liu W, Xiao S, Li W*, Li W*. Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming. Cell Proliferation, 2021 Aug;54(8): e13080.

4. Wang L^#, Zhang R^#, Wu B, Li W*, Li S*, Liu C*. Autophagy mediated tubulobulbar complex components degradation is required for spermiation. Fundamental Research, 2022, 10(50)

5. Wang L^#, Cao C^#, Wang F, Zhao J*, Li W*. H2B ubiquitination: Conservedmolecular mechanism, diverse physiologic functions of the E3 ligase during meiosis. Nucleus, 2017, 8(5):461-468.

6. Liu C^#, Wang L^#, Li Y^#, Guo M, Hu J, Wang T, Li M, Yang Z, Lin R, Xu W, Chen Y, Luo M, Gao F, Chen JY, Sun Q, Liu H, Sun B*, Li W*. RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. Nucleic Acids Res. 2023 Aug 11;51(14):7357-7375.

7. Liu C^#, Xu W^#, Wang L^#, Yang Z^#, Li K^#, Hu J, Chen Y, Zhang R, Xiao S, Liu W, Wei H, Chen JY, Sun Q*, Li W*. Dual roles of R-loops in the formation and processing of programmed DNA double-strand breaks during meiosis. Cell Biosci. 2023 May 11;13(1):82.