李婧禾

博士后

个人简介

李婧禾，博士，2013年毕业于上海中医药大学临床医药结合方向毕业，同年取得国家医师执照。 于2015年4月至2022年3月留学日本，2017年4月至2022年3月在日本横滨市立大学著名内分泌专家-寺内康夫实验室进行博士学位攻读， 且同时于2021年4月至2022年3月，聘为外国人教员在日本国立群马大学生体调节研究所，代谢领域专家白川纯实验室继续深造工作。项目申请人致力于细胞内质网稳态的机制研究，已发表SCI论文5篇。 在攻读博士学位期间，使用代谢紊乱模型Akita小鼠时，发现雌雄鼠激素稳态的不同出现的的糖代谢不同，注意到性激素调控代谢稳态的问题。回国后，继续聚焦于细胞内质网稳态相关的机制研究，并对内分泌激素紊乱导致相关的衰老疾病产生了兴趣。于2022年9月，加入李卫教授组做博士后开展生殖衰老疾病，生殖内分泌疾病相关领域的研究。

研究领域

生殖衰老相关疾病的分子基础，生殖内分泌相关领域

科研成果

主要科研成果（#共同第一作者, *通讯作者）如下：

1. Jinghe Li ; Ryota Inoue; Yu Togashi; Tomoko Okuyama; Aoi Satoh; Mayu Kyohara; Kuniyuki Nishiyama; Takahiro Tsuno; Daisuke Miyashita; Tatsuya Kin; A.M. James Shapiro; Resilind Su Ern Chew; Adrian Kee Keong Teo; Seiichi Oyadomari; Yasuo Terauchi; Jun Shirakawa ; Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway, Diabetes, 2022, 71(3): 424-439


2. Ryota Inoue; Takahiro Tsuno; Yu Togashi; Tomoko Okuyama; Aoi Sato; Kuniyuki Nishiyama; Mayu Kyohara; Jinghe Li ; Setsuko Fukushima; Tatsuya Kin; Daisuke Miyashita; Yusuke Shiba; Yoshitoshi Atobe; Hiroshi Kiyonari; Kana Bando; A. M. James Shapiro; Kengo Funakoshi; Rohit N. Kulkarni; Yasuo Terauchi; Jun Shirakawa ; Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER, iScience, 2022, 25(7): 104603-104603


3. Ryota Inoue; Kuniyuki Nishiyama; Jinghe Li ; Daisuke Miyashita; Masato Ono; Yasuo Terauchi; Jun Shirakawa ; The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes, Cells, 2021, 10(7): 1589


4. Tomoko Okuyama; Jun Shirakawa; Kazuki Tajima; Yoko Ino; Heidrun Vethe; Yu Togashi; Mayu Kyohara; Ryota Inoue; Daisuke Miyashita; Jinghe Li ; Nozomi Goto; Taiga Ichikawa; Shingo Yamasaki; Haruka Ohnuma; Rie Takayanagi; Yayoi Kimura; Hisashi Hirano; Yasuo Terauchi ; Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor. of Insulin Receptor and IGF-1 Receptor, International Journal of Molecular Sciences, 2020,21(21): 7815.


5. Mayu Kyohara; Jun Shirakawa; Tomoko Okuyama; Yu Togashi; Ryota Inoue; Jinghe Li ; Daisuke Miyashita; Yasuo Terauchi ; Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects, Diabetology & Metabolic Syndrome, 2020, 12(1).

代表性论著：

1. Jinghe Li; Ryota Inoue; Yu Togashi; Tomoko Okuyama; Aoi Satoh; Mayu Kyohara; Kuniyuki Nishiyama; Takahiro Tsuno; Daisuke Miyashita; Tatsuya Kin; A.M. James Shapiro; Resilind Su Ern Chew; Adrian Kee Keong Teo; Seiichi Oyadomari; Yasuo Terauchi; Jun Shirakawa; Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway, Diabetes, 2022, 71(3): 424-439

2. Ryota Inoue; Takahiro Tsuno; Yu Togashi; Tomoko Okuyama; Aoi Sato; Kuniyuki Nishiyama; Mayu Kyohara; Jinghe Li; Setsuko Fukushima; Tatsuya Kin; Daisuke Miyashita; Yusuke Shiba; Yoshitoshi Atobe; Hiroshi Kiyonari; Kana Bando; A. M. James Shapiro; Kengo Funakoshi; Rohit N. Kulkarni; Yasuo Terauchi; Jun Shirakawa ; Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER, iScience, 2022, 25(7): 104603-104603

3. Ryota Inoue; Kuniyuki Nishiyama; Jinghe Li; Daisuke Miyashita; Masato Ono; Yasuo Terauchi; Jun Shirakawa ; The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes, Cells, 2021, 10(7): 1589

4. Tomoko Okuyama; Jun Shirakawa; Kazuki Tajima; Yoko Ino; Heidrun Vethe; Yu Togashi; Mayu Kyohara; Ryota Inoue; Daisuke Miyashita; Jinghe Li; Nozomi Goto; Taiga Ichikawa; Shingo Yamasaki; Haruka Ohnuma; Rie Takayanagi; Yayoi Kimura; Hisashi Hirano; Yasuo Terauchi ; Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor. of Insulin Receptor and IGF-1 Receptor, International Journal of Molecular Sciences, 2020,21(21): 7815.

5. Mayu Kyohara; Jun Shirakawa; Tomoko Okuyama; Yu Togashi; Ryota Inoue; Jinghe Li; Daisuke Miyashita; Yasuo Terauchi ; Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects, Diabetology & Metabolic Syndrome, 2020, 12(1).