刘炜炜

博士 研究主管

个人简介

刘炜炜，于石河子大学获得硕士学位，于中科院微生物研究所获得博士学位后，于中科院生物物理研究所从事博后研究。 自博后工作开始主要集中在piwi家族蛋白结合的小非编码RNA（piRNA）通路中关键蛋白的寻找以及其分子机制的研究。

研究领域

非编码RNA调控表观遗传的生物学功能和分子机制

科研成果

主要科研成果（#共同第一作者, *通讯作者）如下：

1. Yuetong Wang#; Jian Cao#; Weiwei Liu#; Jiali Zhang; Zuo Wang; Yiqun Zhang; Linjun Hou; Shengmiao Chen; Piliang Hao; Liye Zhang; Min Zhuang; YangYu; Dake Li; Gaofeng Fan*; Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cance by dephosphorylating and inactivating β-catenin, JBC, 2019, 294(48): 18306-18323.


2. Yuhan Zhang; Weiwei Liu; Ronghong Li; Jiaqi Gu; Ping Wu; Chao Peng; Jinbiao Ma; Ligang Wu; Yang Yu; Ying Huang*; Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, PNAS, 2018, 115(13):3374-3379.


3. Weiwei Liu; Mi Chen; Xinghui Li; Bao Zhao; Junwei Hou; Huaguo Zheng; Lipeng Qiu; Zihai Li; Songdong Meng*; Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response, PLOS ONE, 2016, 11(5).


4. Kang Zhao#; Sha Cheng#; Na Miao#; Ping Xu#; Xiaohua Lu#; Yuhan Zhang#; Ming Wang; Xuan Ouyang; Xun Yuan; Weiwei Liu; Xin Lu; Peng Zhou; Jiaqi Gu; Yiqun Zhang; Ding Qiu; Zhaohui Jin; Chen Su; Chao Peng; Jian-Hua Wang; Meng-Qiu Dong; Youzhong Wan; Jinbiao Ma; Hong Cheng; Ying Huang*; Yang Yu*; A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, Nature Cell Biology, 2019, 21(10): 1261-1272.

代表性论著：

1. Yuetong Wang^#; Jian Cao^#; Weiwei Liu^#; Jiali Zhang; Zuo Wang; Yiqun Zhang; Linjun Hou; Shengmiao Chen; Piliang Hao; Liye Zhang; Min Zhuang; YangYu; Dake Li; Gaofeng Fan*; Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cance by dephosphorylating and inactivating β-catenin, JBC, 2019, 294(48): 18306-18323. doi: 10.1074/jbc.RA119.010348

2. Yuhan Zhang; Weiwei Liu; Ronghong Li; Jiaqi Gu; Ping Wu; Chao Peng; Jinbiao Ma; Ligang Wu; Yang Yu; Ying Huang*; Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, PNAS, 2018, 115(13):3374-3379.

3. Weiwei Liu; Mi Chen; Xinghui Li; Bao Zhao; Junwei Hou; Huaguo Zheng; Lipeng Qiu; Zihai Li; Songdong Meng*; Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response, PLOS ONE, 2016, 11(5).

4. Kang Zhao^#; Sha Cheng^#; Na Miao^#; Ping Xu^#; Xiaohua Lu^#; Yuhan Zhang^#; Ming Wang; Xuan Ouyang; Xun Yuan; Weiwei Liu; Xin Lu; Peng Zhou; Jiaqi Gu; Yiqun Zhang; Ding Qiu; Zhaohui Jin; Chen Su; Chao Peng; Jian-Hua Wang; Meng-Qiu Dong; Youzhong Wan; Jinbiao Ma; Hong Cheng; Ying Huang*; Yang Yu*; A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, Nature Cell Biology, 2019, 21(10): 1261-1272.