覃锡和

博士 研究助理

个人简介

覃锡和，毕业于南方医科大学神经生物学专业，获博士学位；曾担任誉神（广州）医学科技有限公司研发总监； 广州市高层次青年后备人才获得者。主持中国博士后科学基金面上项目1项，参与国家级省部级项目多项：国家自然科学基金重大研究计划培育项目、 国家自然科学基金面上项目、粤港澳大湾区脑科学与类脑研究中心建设开放课题、国家自然科学基金重点项目。

研究领域

1）脑积水治疗新方法与途径研究
2）产后抑郁症发病机制研究与防治

科研成果

主要科研成果（#共同第一作者, *通讯作者）如下：

1. Qin XH #, Wu Z#, Dong JH, Zeng YN, Xiong WC, Liu C, Wang MY, Zhu MZ, Chen WJ, Zhang Y, Huang QY, Zhu XH*. Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress. Cell Rep.22019 Dec 3;29(10):3223-3234.e6. doi: 10.1016/j.celrep.2019.11.006.

2. Zhou JJ #, Qin XH #, Li L, Tian D, Zou ZM, Gu ZT*, Su L*. Heat stress-induced intestinal epithelial cells necroptosis via TLR3-TRIF-RIP3 pathway was dependent on p53. Int Immunopharmacol.2023 Sep;122:110574. doi: 10.1016/j.intimp.2023.110574

3. Li Q , Zhao P#, Wen Y, Zou ZM, Qin XH, Tan HP, Gong J, Wu QH, Zheng C, Zhang K, Huang QB, Maegele M, Gu ZT*, Li L*. POLYDATIN AMELIORATES TRAUMATIC BRAIN INJURY-INDUCED SECONDARY BRAIN INJURY BY INHIBITING NLRP3-INDUCED NEUROINFLAMMATION ASSOCIATED WITH SOD2 ACETYLATION. Shock.2023 Mar 1;59(3):460-468. doi: 10.1097/SHK.0000000000002066.

4. Zhang Y , Zhu MZ, Qin XH, Zeng YN, Zhu XH*. The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin. Front Neurosci .2021 Feb 16;15:631424. doi: 10.3389/fnins.2021.631424.

5. Chen WJ , Wang MY#, Zhu MZ, Xiong WC, Qin XH, Zhu XH*. 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. J Neurosci. 2020 Oct 14;40(42):8188-8203. doi: 10.1523/JNEUROSCI.1246-20.2020.

6. Xiong WC , Cao X, Zeng YN, Qin XH, Cao X, Zeng YN, Qin XH, Zhu MZ, Ren J, Wu Z, Huang QY, Zhang Y, Wang MY, Chen LW, Turecki G, Mechawar N, Chen WJ, Yi GL, Zhu XH*., Zhu MZ, Ren J, Wu Z, Huang QY, Zhang Y, Wang MY, Chen LW, Turecki G, Mechawar N, Chen WJ, Yi GL, Zhu XH*. Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors. J Neurosci. 2019 Jun 5;39(23):4606-4623. doi: 10.1523/JNEUROSCI.3069-18.2019.

代表性论著：

1. Qin XH^#, Wu Z^#, Dong JH, Zeng YN, Xiong WC, Liu C, Wang MY, Zhu MZ, Chen WJ, Zhang Y, Huang QY, Zhu XH*. Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress. Cell Rep.22019 Dec 3;29(10):3223-3234.e6. doi: 10.1016/j.celrep.2019.11.006.

2. 2. Zhou JJ^#, Qin XH^#, Li L, Tian D, Zou ZM, Gu ZT*, Su L*. Heat stress-induced intestinal epithelial cells necroptosis via TLR3-TRIF-RIP3 pathway was dependent on p53. Int Immunopharmacol.2023 Sep;122:110574. doi: 10.1016/j.intimp.2023.110574

3. Li Q^#, Zhao P^#, Wen Y, Zou ZM, Qin XH, Tan HP, Gong J, Wu QH, Zheng C, Zhang K, Huang QB, Maegele M, Gu ZT*, Li L*. POLYDATIN AMELIORATES TRAUMATIC BRAIN INJURY-INDUCED SECONDARY BRAIN INJURY BY INHIBITING NLRP3-INDUCED NEUROINFLAMMATION ASSOCIATED WITH SOD2 ACETYLATION. Shock.2023 Mar 1;59(3):460-468. doi: 10.1097/SHK.0000000000002066.

4. Zhang Y, Zhu MZ, Qin XH, Zeng YN, Zhu XH*. The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin. Front Neurosci.2021 Feb 16;15:631424. doi: 10.3389/fnins.2021.631424.

5. Chen WJ^#, Wang MY^#, Zhu MZ, Xiong WC, Qin XH, Zhu XH*. 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. J Neurosci. 2020 Oct 14;40(42):8188-8203. doi: 10.1523/JNEUROSCI.1246-20.2020.

6. Xiong WC, Cao X, Zeng YN, Qin XH, Cao X, Zeng YN, Qin XH, Zhu MZ, Ren J, Wu Z, Huang QY, Zhang Y, Wang MY, Chen LW, Turecki G, Mechawar N, Chen WJ, Yi GL, Zhu XH*., Zhu MZ, Ren J, Wu Z, Huang QY, Zhang Y, Wang MY, Chen LW, Turecki G, Mechawar N, Chen WJ, Yi GL, Zhu XH*. Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors. J Neurosci. 2019 Jun 5;39(23):4606-4623. doi: 10.1523/JNEUROSCI.3069-18.2019.