连祺周

博士 高级研究员 博士生导师

个人简介

连祺周教授，高级研究员，博士研究生导师。1999年毕业于哈尔滨医科内科学医学博士学位，在新加坡国立大学医学院、 新加坡基因组研究院完成博士后训练，后就职于新加坡国立大学医学院、香港大学李嘉诚医学院内科学系及香港大学细胞治疗中心。 现担任广州市妇女儿童医疗中心优生围产研究所脐血库主任。其领导的实验室在国际上率先建立多能干细胞来源的间充质干细胞及应用于心血管病治疗； 建立多能干细胞来源的免疫细胞和肺脏类器官生物模型，应用于新冠病毒的研究及药物筛选。在香港大学创立首个细胞治疗和基因治疗国际GMP标准制造中心； 领导亚洲首宗造血干细胞基因治疗，成功挽救了致命性异染性脑白质退化症患者；目前承担国家科技部重点研发计划“干细胞研究与器官修复”课题负责人(2023.1-2027.12)；香港重大主题研究课题负责人(2020-2025)等

研究领域

1.以干细胞为平台，结合临床样本、模式动物及多组学技术研究心肺、血管及代谢性疾病的分子机制
2.新型的细胞治疗和基因治疗技术
3.间充质干细胞及细胞外囊泡

科研成果

在科学期刊包括Circulation，CellStem Cell , Nature Metabolism，Nature Communications等发表了论文130多篇。论文引用超过7505 次， H-index 指数 40 (GoogleScholar)。主要科研成果（#共同第一作者,*通讯作者）如下：

1.Jin L#, Geng L#, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q*, Xu A*. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity. Circulation. 2022 Sep 22. doi: 10.1161/CIRCULATIONAHA.122.059631.


2.Geng L, Liao B, Jin L, Yu J, Zhao X, Zhao Y, Zhong L, Wang B, Li J, Liu J, Yang JK,Jia W,Lian Q*, Xu A*. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion viaGP130. NatMetab.2022 May;4(5):608-626. doi: 10.1038/s42255-022-00572-2.


3.Zhang Z, Yan B, Gao F, Li Q, Meng X, Chen P, Zhou L, Deng W, Li C, Xu W, Han S, Feng H, Li Y, Chen J, Yin Z, Liao C, Tse HF*, Xu A*, Lian Q*. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. /em>Mol Ther. 2020 Dec 2;28(12):2642-2661. doi: 10.1016/j.ymthe.2020.07.024.


4. Zhang Y#, Zhang Z#, Chen P, Ma CY, Li C, Au TYK, Tam V, Peng Y, Wu R, Cheung KMC, Sham PC, Tse HF, Chan D, Leung VY, Cheah KSE*, Lian Q*. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Rep. 2020 Feb 25;30(8):2791-2806.e5. doi: 10.1016/j.celrep.2020.01.100.


5. Jiang D#, Xiong G#, Feng H, Zhang Z, Chen P, Yan B, Chen L, Gandhervin K, Ma C, Li C, Han S, Zhang Y, Liao C, Lee TL, Tse HF, Fu QL, Chiu K, Lian Q*. Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration. Theranostics. 2019 Apr 13;9(8):2395-2410. doi: 10.7150/thno.29422.


6.Li X#, Michaeloudes C#, Zhang Y, Wiegman CH, Adcock IM, Lian Q*, Mak JCW*, Bhavsar PK*, Chung KF*. Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways. J Allergy Clin Immunol. 2018 May;141(5):1634-1645.e5. doi: 10.1016/j.jaci.2017.08.017.

代表性论著

1. Jin L^#, Geng L^#, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q*, Xu A*. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity. Circulation. 2022 Nov 15;146(20):1537-1557. doi: 10.1161/CIRCULATIONAHA.122.059631.

2. Geng L, Liao B, Jin L, Yu J, Zhao X, Zhao Y, Zhong L, Wang B, Li J, Yang JK, Jia W, Lian Q*, Xu A*. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130. Nat Metab. 2022 May;4(5):608-626. doi: 10.1038/s42255-022-00572-2.

3. Zhang Z, Yan B, Gao F, Li Q, Meng X, Chen P, Zhou L, Deng W, Li C, Xu W, Han S, Feng H, Li Y, Chen J, Yin Z, Liao C, Tse HF*, Xu A*, Lian Q*. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. Mol Ther. 2020 Dec 2;28(12):2642-2661. doi: 10.1016/j.ymthe.2020.07.024.

4. Zhang Y^#, Zhang Z^#, Chen P, Ma CY, Li C, Au TYK, Tam V, Peng Y, Wu R, Cheung KMC, Sham PC, Tse HF, Chan D, Leung VY, Cheah KSE*, Lian Q*. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Rep. 2020 Feb 25;30(8):2791-2806.e5. doi: 10.1016/j.celrep.2020.01.100.

5. Jiang D^#, Xiong G^#, Feng H, Zhang Z, Chen P, Yan B, Chen L, Gandhervin K, Ma C, Li C, Han S, Zhang Y, Liao C, Lee TL, Tse HF, Fu QL, Chiu K, Lian Q*. Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration. Theranostics. 2019 Apr 13;9(8):2395-2410. doi: 10.7150/thno.29422.

6. Li X^#, Michaeloudes C^#, Zhang Y, Wiegman CH, Adcock IM, Lian Q*, Mak JCW*, Bhavsar PK*, Chung KF*. Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways. J Allergy Clin Immunol. 2018 May;141(5):1634-1645.e5. doi: 10.1016/j.jaci.2017.08.017. Epub 2017 Sep 11. PMID: 28911970.