李杰

博士 教授 主任医师 博士生导师

EMAIL：LIJIE2958@GWCMC.ORG

个人简介

李杰，博士，主任医师，博士生导师，博士后合作导师，广州市妇女儿童医疗中心甲状腺乳腺疾病诊疗中心学科带头人、科主任，优生围产研究所PI， 原中山大学附属第一医院血管甲乳中心专科副主任，广东省普通外科质控中心甲乳外科学组副组长， 美国哈佛大学麻省总院 (MGH)博士后/访问学者，纽约斯隆凯瑟琳癌症中心(MSKCC) 访问学者，意大利比萨大学、 比利时鲁汶大学访问学者，中国临床肿瘤学会(CSCO) 青年常务委员，广东省癌症中心乳腺癌诊治质量控制专家委员会常委， 近年来在国内外专业杂志发表论文50余篇，其中包括Signal Transduction and Targeted Therapy、Molecular Cancer、 JAMA Surgery、Cancer Research、Cell Death and Differentiation、Oncogene、International Journal of Cancer 等，主编、参编或参译专著8部，近年来主持/参与包括国家自然科学基金在内的国家级、省部级科研基金多项。

社会与学术兼职

担任中国临床肿瘤学会（CSCO）青年常务委员、中国临床肿瘤学会（CSCO）甲状腺分会委员、中国抗癌协会乳腺分会（CBCS）青年委员、中国研究型医院学会甲状腺专业委员会青年委员、中国医师协会科学普及分会甲状腺科普专委会委员、广东省抗癌协会甲状腺癌青年委员会主任委员、广东省临床医学会甲状腺青年委员会副主任委员 、广东省普通外科质控中心甲乳外科学组副组长、广东省抗癌协会甲状腺分会常务委员。

研究领域

离子代谢调控机体稳态机制和代谢重编程和免疫调控机制研究。

科研成果

近五年团队以第一或通讯作者在国内外专业杂志发表论文50余篇，其中包括Molecular Cancer*3（IF 41.44）、Signal Transduction and Targeted Therapy（IF 38.104）、Lancet Digital Health（IF 36.615）、Nature cell biology （IF 28.213）、Journal of Hematology & Oncology（23.168）、JAMA Surgery*2（IF16.681）、Cancer Research（13.312）、Cell Death and Differentiation（IF 12.067）、JNCI*2 (11.816)、Oncogene*2（IF 8.756）、International Journal of Cancer（IF 7.316）等。。主要科研成果（#共同第一作者, *通讯作者）如下：

1. Wang Sun Z#, Jiang Q#, Gao B#, Zhang X, Bu L, Wang L, Lin Y, Xie W, Li J*, Guo J*. AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis. Cancer Res.2023 Aug 21;33(16):3371-3388.e7. 2023 Apr 14;83(8):1264-1279.

2. Wang Xie W#, Jiang Q#, Wu X#, Wang L#, Gao B, Sun Z, Zhang X, Bu L, Lin Y, Huang Q,Li J*, Guo J*. IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. Cell Death Differ.2022 Jan 22.

3. Wang Chen W#, Li J#, Peng S#, Hong S#, Xu H#, Lin B#, Liang X, Liu Y, Liang J, Zhang Z, Ye Y, Liu F, Lin C, Xiao H*, Lv W*. Association of Total Thyroidectomy or Thyroid Lobectomy With the Quality of Life in Patients With Differentiated Thyroid Cancer With Low to Intermediate Risk of Recurrence. JAMA Surg. 2022 Mar 1;157(3):200-209.

4. Zhang L#, Wu ZY#, Li J#, Lin Y, Liu Z, Cao Y, Zhang G, Gao HF, Yang M, Yang CQ, Zhu T, Cheng MY, Ji F, Li J, Wang K*. Neoadjuvant docetaxel plus carboplatin vs epirubicin plus cyclophosphamide followed by docetaxel in triple-negative, early-stage breast cancer (NeoCART): Results from a multicenter, randomized controlled, open-label phase II trial. JInt J Cancer. 2022 Feb 15;150(4):654-662.

5. Yu S#, Liu C#, Hou Y#, Li J#, Guo Z, Chen X, Zhang L, Peng S, Hong S, Xu L, Li X, Liu R, Chen S, Li B, Weng Z, Li Y, Lv W*, Yu J*, Xiao H*. Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer. Oncogene. 2022 Apr;41(17):2422-2430.

6. 5. Hong S#, Xie Y#, Cheng Z#, Li J#, He W, Guo Z, Zhang Q, Peng S, He M, Yu S, Xu L, Liu R, Xu T, Zhang Y, Li Y, Wang J*, Lv W, Yu J*, Xiao H* . Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability. Oncogene. 2022 Nov;41(47):5121-5132.

7. Huang J#, Zheng L#, Sun Z#, Li J*. CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review). Int J Mol Med. 2022 Oct;50(4):128.

8 Li J#, Gao X#, Zhang Z#, Lai Y#, Lin X, Lin B, Ma M, Liang X, Li X, Lv W, Lin Y*, Zhang N*. CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes. Mol Cancer. 2021 Oct 25;20(1):138.


9. Ma M#, Wang M#, Zhang Z, Lin B, Sun Z, Guan H, Lv W*, Li J*. Apolipoprotein A1 is negatively associated with male papillary thyroid cancer patients: a cross-sectional study of single academic center in China. BMC Endocr Disord. 2021 Apr 14;21(1):69.


10. Zheng, L.#, Zheng, F.#, Xing, Z.#, Zhang, Y.#, Li, Y., Xu, H., Lai, Y.*, Li, J.*, & Wang, W*. Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?. BMC Cancer. 2021;21(1):633.


11. Zicheng Sun#, Qiwei Jiang#, Jie Li*, Jianping Guo*. The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis. Signal Transduct Target Ther. 2020 Aug 12;5(1):150.


12. Jie Li#, Maoguang Ma#, Xuesong Yang#, Maolei Zhang#, Jingyan Luo, Huangkai Zhou, Nunu Huang, Feizhe Xiao, Bingquan Lai, Weiming Lv, Nu Zhang*.Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab. Mol Cancer, 2020 Sep 11;19(1):142.


13. Fang Z#, Wang R#, Yang C#, Wang D, Chen W, Lin B, Gong D, Li S, Liang J, Liang X, Zeng C, Li J*, Wang K*, Lv W*. A Novel Predictive Nomogram including Serum Lipoprotein a Level for Nonsentinel Lymph Node Metastases in Chinese Breast Cancer Patients with Positive Sentinel Lymph Node Metastases. Dis Markers. 2021 Nov 22;2021:7879508.


14. Gao X#, Lai Y#, Zhang Z#, Ma Y, Luo Z, Li Y, Yang C*, Lu G*, Li J*. Long Non-coding RNA RP11-480I12.5 Promotes the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-490-3p-AURKA-Wnt/β-Catenin Axis. Front Oncol. 2020 Jul 7;10:948.


15. Ma M#, Lin B, Wang M, Liang X, Su L, Okose O, Lv W*, Li J*. Immunotherapy in anaplastic thyroid cancer. Am J Transl Res. 2020 Mar 15;12(3):974-988.


16. Lin B#, Lu B#, Hsieh IY#, Liang Z, Sun Z, Yi Y, Lv W*, Zhao W*, Li J*. Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer. Front Pharmacol. 2020 May 13;11:632.


17. Hsieh IY#, He J#, Wang L#, Lin B, Liang Z, Lu B, Chen W, Lu G, Li F, Lv W*, Zhao W*, Li J*. H3K27me3 loss plays a vital role in CEMIP mediated carcinogenesis and progression of breast cancer with poor prognosis. Biomed Pharmacother. 2020 Mar; 123:109728. .

代表性论著

1. Sun Z^#, Jiang Q^#, Gao B^#, Zhang X, Bu L, Wang L, Lin Y, Xie W, Li J*, Guo J*. AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis. Cancer Res. 2023 Apr 14;83(8):1264-1279. doi: 10.1158/0008-5472.CAN-22-3407.

2. Xie W^#, Jiang Q^#, Wu X^#, Wang L^#, Gao B, Sun Z, Zhang X, Bu L, Lin Y, Huang Q, Li J*, Guo J*. IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. Cell Death Differ. 2022 Aug;29(8):1528-1540. doi: 10.1038/s41418-022-00940-1.

3. Chen W^#, Li J^#, Peng S^#, Hong S^#, Xu H^#, Lin B^#,, Liang X, Liu Y, Liang J, Zhang Z, Ye Y, Liu F, Lin C, Xiao H*, Lv W*. Association of Total Thyroidectomy or Thyroid Lobectomy With the Quality of Life in Patients With Differentiated Thyroid Cancer With Low to Intermediate Risk of Recurrence. JAMA Surg. 2022 Mar 1;157(3):200-209. doi: 10.1001/jamasurg.2021.6442.

4. Li J^#, Gao X^#, Zhang Z^#, Lai Y^#, Lin X, Lin B, Ma M, Liang X, Li X, Lv W, Lin Y*, Zhang N*. CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes. Mol Cancer. 2021 Oct 25;20(1):138. doi: 10.1186/s12943-021-01444-1.

5. Sun Z^#, Jiang Q^#, Li J*, Guo J*. The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis. Signal Transduct Target Ther. 2020 Aug 12;5(1):150. doi: 10.1038/s41392-020-00265-w.

6. Li J^#, Ma M^#, Yang X^#, Zhang M^#, Luo J, Zhou H, Huang N, Xiao F, Lai B, Lv W, Zhang N*. Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab. Mol Cancer. 2020 Sep 11;19(1):142. doi: 10.1186/s12943-020-01259-6.